Celiac disease is an autoimmune disorder in which the body mistakenly reacts to gluten, a protein found in wheat, barley, and rye, as if it were a poison. It affects as many as one in 141 people, although most have not been diagnosed. When someone with celiac consumes gluten, the immune system reacts by destroying the part of the small intestine that absorbs vital nutrients. This malabsorption can lead to serious illness.

SYMPTOMS OF CELIAC

The list of symptoms related to celiac covers the entire body, including gas, bloating, diarrhea, weight loss or gain, abdominal pain, constant fatigue or weakness, headaches, depression that does not respond to medication, bone pain and anemia. For children, symptoms include failure to thrive, short stature, distended abdomen, dental enamel defects and unusual behavior changes. The nervous system can also be affected by the disease, but many patients with neurological symptoms—and their doctors—don’t make the connection.

Small fiber neuropathy is the common symptom involving the nervous system. “It typically presents with numbness, tingling or painful burning, stinging or electric-shock like sensations, usually in the arms or legs, but sometimes [in] the torso or face,” says Norman Latov, M.D., Ph.D., a professor of neurology and neuroscience and the director of the Peripheral Neuropathy Clinical and Research Center at Weill Cornell Medical College. Small fiber neuropathy can also cause dizziness or feeling faint when standing up, sexual dysfunction, abnormal sweating, bladder symptoms, hair loss or skin changes. General lack of familiarity with small fiber neuropathy complicates the picture for patients with undiagnosed celiac. Their symptoms are often dismissed or misdiagnosed as fibromyalgia, so the association with celiac may be missed, according to Latov.

And small fiber neuropathy is only one of the neurological symptoms of celiac. “Less-common neurological conditions include cerebellar ataxia with unsteadiness or incoordination, seizures or neuropsychiatric disorders,” he says. Headaches are another potential symptom, but their prevalence adds a layer of complexity when it comes to diagnosis. “Headaches are common in the general population, however, so that it’s difficult to know whether gluten is the cause or only an aggravating factor,” Latov says.

The presence of neurological symptoms raises questions about whether there is a connection between the brain and the gut. “Adult patients often present with neurologic symptoms in the absence of gastrointestinal symptoms, so celiac disease may not come to mind,” according to Latov, who has a clinical and research interest in peripheral neuropathy and has done celiac disease research. Currently there are two theories on why neurological symptoms develop. In both, Latov says, “stimulation of the immune system by gluten in the diet would increase the inflammation in both the gut and nervous system.” The good news is neurologists are beginning to become more aware of this brain-gut connection. “It is improving but very slowly,” Latov says, noting education of both patients and doctors is important. “Perhaps with greater awareness, neurologists will play a larger role in the diagnosis of celiac disease.”

Celiac is tricky, however, and sometimes has no outward symptoms. Since it is a genetic disease, relatives of those who have been diagnosed have an increased risk.

SKIN SYMPTOMS OF CELIAC

There is also a skin form of celiac called dermatitis herpetiformis (DH), which appears clusters of bumps or blisters on the forearms, elbows, knees, buttocks or hairline. According to Nicole Seminara, M.D., assistant professor in the Ronald O. Perelman Department of Dermatology at NYU Langone Medical Center, the bumps and blisters characteristic of DH are “intensely itchy [and] people usually scratch them off before they ever present to a doctor.” The condition, which tends to develop in patients who are in their 30s and 40s, is diagnosed through a special skin biopsy. The connection between DH and celiac is something dermatologists “are very aware of…and take very seriously,” says Seminara. “If I have a patient with DH,” she says, he or she is “always sent to [a gastroenterologist]” to be tested for celiac.

When it comes to healing DH, the gluten-free diet is key—as is patience. While the drug Dapsone can help ease discomfort caused by the rash, it does not replace the gluten-free diet, which is the only way to rid a patient of DH.

DIAGNOSING CELIAC

Diagnosis of celiac begins with a blood test, or serology. The simple test can be done at a physician’s office, with results provided in a few days. The test looks for specific biomarkers, known as anti-tissue transglutaminase (tTG) antibodies, indicative of celiac.

Those with evidence of celiac undergo an endoscopy to confirm the diagnosis. During an endoscopy, the patient is put under anesthesia and doctors insert a tube through the mouth and into the small intestine to biopsy a few samples of the intestinal lining. After the procedure, doctors might have some idea how likely celiac is based on what they’ve observed, but they cannot confirm the diagnosis until the biopsy sample is analyzed by a pathologist. That procedure usually takes a few days.

TREATING CELIAC

The only treatment for celiac disease is to follow the gluten-free diet. When gluten is taken out of the diet, the small intestine heals and a return to full health can be expected. Long-term complications of undiagnosed celiac include malnutrition, lymphoma, osteoporosis, neurological complications and miscarriage.

If you are seeking more research on symptoms and causes try this link to another resource.

This material is not intended to provide medical advice, which should be obtained directly from a physician.