"Is Gluten Sensitivity Real?" In 1980, researchers in England
reported a series of women who suffered from chronic diarrhea
that resolved on a gluten-free diet, yet did not have evidence of celiac disease,
the autoimmune disorder associated with gluten intolerance. The medical profession was skeptical
at the time, and even 30 years later, so much so, that much like patients
who had irritable bowel syndrome, patients claiming non-celiac gluten sensitivity
were commonly referred to psychiatrists because they were believed to have
an underlying mental illness. Psychological testing of such patients,
however, found no evidence that they were suffering from some
kind of psychosomatic hysteria. The medical profession has a history of
dismissing diseases as all in people’s heads— PTSD, ulcerative colitis, migraines,
ulcers, asthma, Parkinson’s, MS. Despite resistance from the prevailing
medical community at the time, these health problems have subsequently been confirmed to be credible physiologically-based disorders rather than psychologically-based confabulations. On the flip side, the Internet is rife with
unsubstantiated claims about gluten free diets, which has spilled over into the popular press
to make gluten the diet villain du jour with claims like ‘17 million
Americans are gluten sensitive.’ However, it must be remembered
that this is also ‘big business.’ When literally billions of dollars are
at stake, it’s hard to trust anybody, so as always, best to stick to the science.
What sort of evidence do we have for the existence
of a condition presumed to be so widespread? Not much. The evidence base for such claims
was unfortunately very thin because we didn’t have randomized controlled trials demonstrating that the entity even exists. The gold-standard for confirming non-celiac
gluten sensitivity requires a gluten-free diet, followed by a double-blind, randomized,
placebo-controlled food challenge. Like you give someone a muffin
and they’re not told if it’s a gluten free muffin or gluten filled
muffin – to control for placebo effects – and see what happens.
The reason this is necessary is
because when you actually do this, a number of “gluten-sensitive”
patients don’t react at all to disguised gluten, and instead react to the gluten-free
placebo, so it truly was in their heads. But we never had that kind of
level of evidence until 2011, when a double-blind, randomized placebo-
controlled trial was published, which tested to see if patients complaining
of irritable bowel type symptoms, who claimed they felt better on a gluten free
diet – despite not having celiac disease – actually could tell if they were given gluten-free bread
and muffins or gluten-containing bread and muffins. They started out gluten-free
and symptom-free for two weeks and then they were challenged
with the bread and muffins. Here’s what happened to the 15
patients who got the placebo, meaning they started out on a gluten-free
diet and continued on a gluten-free diet.
They got worse. Just the thought that they may be eating
something that was bad for them made them feel all crampy and bloated. This is what’s called a nocebo effect. The placebo effect is when you give someone
something useless and they feel better. The nocebo effect is when you give someone
something harmless and they feel worse. But the small group that got
the actual gluten felt worse still. So, they concluded, this non-celiac
gluten intolerance may actually exist. It was a small study, though, and even though they claimed the gluten-free bread and muffins were indistinguishable, maybe at some level the patients
could tell which is which. So in 2012, researchers in Italy took 920 patients that
had been diagnosed with non-celiac gluten sensitivity and put them to the test with a double-blinded wheat
challenge by giving them not bread and muffins, but capsules filled with wheat flour or filled with
placebo flour, kind of a placebo powder – no flour at all.
And more than two-thirds failed the test, like they
got worse on the placebo or better on the wheat. But of those that passed, there was a clear benefit
to staying on the wheat-free diet, confirming the
existence of a non-celiac wheat sensitivity. Now note they said wheat sensitivity,
not gluten sensitivity. Gluten itself may not be causing gut symptoms at all. See, most people with wheat sensitivity
have a variety of other food sensitivities. Two thirds are sensitive to cow’s milk protein as well, then eggs were the most common culprit after that. So if you put people on a diet low in
common triggers of irritable bowel symptoms and then challenge them with gluten,
there’s no effect.
Same increase in symptoms with high gluten,
low gluten, or no gluten, calling into question
the very existence of non-celiac gluten sensitivity. Interestingly, despite being informed that avoiding
gluten wasn’t apparently doing a thing for their gut symptoms, many participants opted to continue following a gluten-free diet as they just subjectively described “feeling better.” So the researchers wondered if avoiding gluten might
be improving the mood of those with wheat sensitivity, and indeed, short-term exposure to gluten appeared
to induce feelings of depression in these patients. But whether non-celiac gluten sensitivity is a disease of the mind or the gut, it is no longer a condition that can be dismissed..
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